(click on each thumbnail for a full-size image)
EGAN contains a point-and-click wizard to help the user load custom/proprietary data sets formatted using other software such as Microsoft Excel.
EGAN allows dynamic gene list construction via combination of analysis results from multiple experiments and technology platforms; don't be constrained by ad-hoc p-value/FDR cutoffs!
EGAN contains links between every node and its corresponding web database entry as well as links from edges to over 250k articles at PubMed.
EGAN automatically generates comprehensive gene set enrichment statistics for your gene lists and experiment results.
EGAN displays genes and enriched gene sets on an interactive hypergraph.
EGAN enables discovery of informative protein interaction modules by combining significant genes from an assay (nodes with lighter gray background) with enriched 'bridging' genes (nodes with darker gray background).
Even without experimental data, EGAN enables biology-driven data mining and visualization beyond Venn Diagrams; shown are the shared and unshared genes between disparate gene sets associated with Wnt signaling.
EGAN can assist in the investigation of gene function, by identifying and characterizing all protein-protein interaction partners (ANXA1 and all its known PPI neighbors are shown with enriched gene sets). Also note the white background which can be used to produce publication-quality PDF figures.
Shown are Wnt signaling genes from the previous image with enriched miRNA target gene sets, providing instant in-silico prediction and visualization of miRNA regulators of Wnt signaling (unconnected genes not shown).
EGAN provides deeper investigation into results of GSEA-like global enrichment statistics via histogram, box-and-whisker plot and an interactive QQ plot layout algorithm.
EGAN integrates as a plug-and-play visualization/downstream analysis module in a robust -omics analysis pipeline (e.g. GenePattern).